====== Tutorial 1 - Introduction, Assignment: WEB SEARCH, Bioinformatics databases  ======

===== 1 - Biology primer =====

See {{courses:bin:bin_cv_1.pdf|slides}}.

===== 2 - In lab web search ====

Use google, NCBI database, Ensembl genome assembly, ENA archive, Wikipedia, UniProt or whatever you need to answer the following questions.

  - How long is the genome of the following species? How many chromosomes do they have? Is their genome complete? How many genes do they have? [adapted from [[http://tbb.bio.uu.nl/BDA/2017/BioInf2017.pdf|http://tbb.bio.uu.nl/BDA/2017/BioInf2017.pdf]] ]
    * Human papillomavirus
    * Covid-19
    * Drosophila melanogaster
    * Human sapiens
  - Download the sequence of Human papillomavirus. What does it start with?
  - Who published the reference genome of Human papillomavirus and when?
  - Find the TP53 gene. What is it good for and how the connected mechanism works? Where can you find it?
  - Is it possible to find the TP53 gene in chimpanzee?
  - Find an image of the tertiary structure of the p53 protein.
  - How many isoforms of p53 are known? What is an isoform?
    

===== 3 - Assignment 1 - web search =====

Work individually on the [[courses:bin:assignments:hw1|first homework assignment]].